For Research Use Only — Not for Human Consumption
For Research Use Only — Not for Human Consumption
Melanotan II (MT-2) is a synthetic analogue of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). In laboratory settings, it is utilized to study melanogenesis, energy homeostasis, and central nervous system pathways through its non-selective agonism of melanocortin receptors.
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Batch #23MT2-0726 | HPLC & MS Analysis Verified
Melanotan II is a cyclic, shortened synthetic version of alpha-melanocyte-stimulating hormone (α-MSH). It features a distinct lactam bridge and specific amino acid substitutions, including the integration of a D-phenylalanine residue. These structural modifications protect the peptide from rapid extracellular degradation, making it highly stable with a significantly extended half-life for comprehensive in-vitro and animal model studies compared to native α-MSH.
Current laboratory research focuses on its robust, non-selective binding profile to melanocortin receptors, primarily MC1R, MC3R, and MC4R. In-vitro models utilize Melanotan II to observe its regulatory effects on melanin production (melanogenesis) via the MC1R receptor. Furthermore, researchers study its systemic interactions, particularly its influence on feeding behavior, energy expenditure, and erectile/arousal functions mediated through MC3R and MC4R pathways in the central nervous system.
Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.
Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study.
Skin darkening and erectile activity in humans after subcutaneous injection of a synthesized alpha-melanocyte stimulating hormone analog (Melanotan-II).
Melanotan-II causes hypophagia and uremia in rats
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